Alberta Alickaj - Storming Media

The Role of DARPP-32, an Intracellular Signaling Molecule, in the Actions of the Nerve Agent Sarin

AUG 2005

25 pages

Authors: Tsung-Ming Shih; Gretchen L. Snyder; Allen A. Fienberg; Stacey Galdi; Minal Rana; Alberta Alickaj; Joseph P. Hendrick; John H. McDonough; ARMY MEDICAL RESEARCH INST OF CHEMICAL DEFENSE ABERDEEN PROVING GROUND MD

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We investigated the role of DARPP-32 in mediating changes in phosphorylation after sarin exposure. Wild type mice and mice bearing a targeted disruption of the gene for DARPP-32 were exposed to sarin; levels of brain phosphoproteins were measured. Mice receiving 1.0 x LD50 dose of sarin displayed motor convulsions. No significant change in phosphorylation level of T75 DARPP-32 was observed in brains of wild type mice. Also, no significant changes ...