| Estrogen Metabolism Genes and Breast Cancer: An Innovative Approach |
JUL 2004 |
37 pages |
| Authors:
Habibul Ahsan; COLUMBIA UNIV NEW YORK
|
 | We proposed to examine associations of CYP17, CYPl9, CYP1BI, and COMT polymorphisms and breast cancer risk using an innovative family-based design among families participating in the Metropolitan New York Breast Cancer Registry (MNYBCR), one of the six sites for National Cancer Institute (NCT)-initiated Cooperative Family Registry for Breast Cancer Studies (CFRBCS) project. To date, we have accomplished all tasks in the approved Statement of Work as planned. We found the ... |
|
| Association Between Offspring's hCG Genotype and Breast Cancer Risk in Mothers: A Novel Approach |
JUN 2004 |
5 pages |
| Authors:
Habibul Ahsan; COLUMBIA UNIV NEW YORK
|
| We proposed to examine the novel hypothesis that the hCG genotype of a woman's off spring is associated with her breast cancer risk. Using the existing Metropolitan New York Registry (MNYR) resources, a case-control study was designed to examine the hypothesis whether first-born offspring's hCGbeta 5 genotype (i.e., placental hCGbeta 5 genotype during first FTP) is associated with a woman's breast cancer risk. To date, the three tasks in the ... |
|
| Association Between Offspring's hCG Genotype and Breast Cancer Risk in Mothers: A Novel Approach |
JUN 2003 |
5 pages |
| Authors:
Habibul Ahsan; COLUMBIA UNIV NEW YORK
|
| We proposed to examine the novel hypothesis that the hCG genotype of a woman's offspring is associated with her breast cancer risk. Using the existing Metropolitan New York Registry (MNYR) resources, a case-control study was designed to examine the hypothesis whether first-born offspring's hCGbeta 5 genotype (i.e., placental hCGP 5 genotype during first FTP) is associated with a woman's breast cancer risk. To date, the three tasks in the approved ... |
|
| Cytochrome p450-17alpha Polymorphism and Risk of Breast Cancer |
AUG 2000 |
5 pages |
| Authors:
Habibul Ahsan; COLUMBIA UNIV NEW YORK
|
| Previous studies indicate that circulating estradiol is significantly elevated in breast cancer patients compared to controls in high and low risk populations. A variation in enzyme activity, i.e., the polymorphism of genes encoding the enzymes responsible for the metabolism and binding of estrogen may be related to an altered risk of breast cancer. The cytochrome P45O17a, an enzyme involved in estrogen biosynthesis has shown the most potential in the etiology ... |
|
| Cytochrome P450-17alpha Polymorphism and Risk of Breast Cancer |
AUG 1999 |
6 pages |
| Authors:
Habibul Ahsan; COLUMBIA UNIV NEW YORK
|
| The current study investigates whether polymorphisms in the CYP 17 gene, which plays roles in estrogen biosynthesis, are associated with an altered risk of breast cancer in a population-based sample of women (400 cases and 400 controls) who participated in the Long Island Breast Cancer Study Project (LIBSCP). In addition, we are also exploring whether the effects of reproductive risk factors and exposure to exogenous estrogen are modified by CYP ... |
|
Reports by Author
