The last year, which was funded by the DOD collaborative Breast Cancer Idea Award, has resulted in several important translational and basic science findings. Specifically, the most significant finding during the research period were: (1) the identification of MnSOD as a legitimate Sirt3 deacetylation target that for the first time shows that post-translation modifications of mitochondrial proteins plays a role in mitochondrial function (published in Molecular Cell); (2) that Sirt3 ...
The goals of this synergistic project are to establish the mitochondria localized sirtuin protein SIRT3 as a tumor suppresso breast cancer and to define its role as a molecular link between aging and breast cancer. Sirt3 knockout mice develop ER/P positive breast tumors later in life. These ER/PR-positive tumors are histologically similar to breast tumors common in old women. In humans, loss of SIRT3 is seen in a significant fraction ...
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