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Abstract:
Estrogen plays a critical role in the development and progression of breast cancer. While endocrine therapies play an important part in breast cancer treatment, the failure of these therapies reflects a lack of knowledge concerning the molecular mechanisms involved in estrogen signaling. The biological activities of estrogen are mediated by estrogen receptors (ER) . In addition, a large number of proteins termed cofactors are involved in ER signaling. Until recently, our knowledge regarding these cofactors was based on their ability to bind receptors in vitro and affect transcriptional activation in transfection experiments. The in vivo role of these cofactors and the specific target genes involved in breast cancer are not well known.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual summary rept. 1 Jul 2001-30 Jun 2002 |
| Pages: |
23 |
| Report Date: |
JUL 2002 |
| Contract Number: |
DAMD17-01-1-0222 |
| Report Number: |
A996214 |
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Keywords relating to this report:
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