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Abstract:
The proposed studies seek to explore cellular and molecular aspects of p53 function that may contribute to the development and progression of breast cancer. The hypotheses are: (1) that p53 and a novel physiological splicing variant, p53as, have distinct stability in cells, distinct expression during the cell cycle, and distinct associated proteins; (2) that p53as has different specificity or affinity for DNA binding sequences than p53; and (3) that p53 and p53as mRNA and protein are differentially expressed in mouse mammary preneoplastic and neoplastic cells and tissues with implications for breast cancer detection, prognosis or treatment.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 1 Oct 94-30 Sep 95 |
| Pages: |
51 |
| Report Date: |
OCT 95 |
| Contract Number: |
DAMD17-94-J-4341 |
| Report Number: |
A981303 |
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