Abstract: The goal of this ARO/DARPA funded project is to develop a fully integrated microfluidic device that would be capable of electronically detecting specific bacterial pathogens in whole blood, and other fluids such as sputum and urine. The integrated device consists of two sensors: a microscale Coulter counter that sizeds and then fractionates blood samples based on particulate size; and an on-chip high frequency spectrometer that interrogates the dielectric response of an unknown pathogen (bacteria, protozoa, or yeast) at specific frequencies. A library of frequencies corresponding to known cell types will ultimately map to the spectral response of the unknown organism, thus permitting very rapid identification of species and form (i.e. vegetative vs. spore). An integral part of the proposed work is the integration of these two sensors into a compact, microfluidic device. Crucial to the success of this integration is the utilization of microfluidic tectonics (microFT) developed by the Beebe group at the University of Wisconsin-Madison.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Final rept. Jul 2000-Jun 2003 |
| Pages: |
54 |
| Report Date: |
JUN 2003 |
| Contract Number: |
DAAD19-00-1-0369 |
| Report Number: |
A925514 |
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