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Abstract:
We compared the immune response of BALB/c mice to two biological agents, Coxiella burnetii and Burkholderia mallei. Both C. burnetii and B. mallei cell preparations induced a proliferative and a mixed Th1- and Th2-like cytokine response in splenocytes from vaccinated mice. B. mallei cell preparations induced higher levels of IgG and IgM than did C. burnetii. The ratio of the subclasses IgG2a over IgG1 from C. burnetii vaccinated mice was higher than 1.0, while the ratio from B. mallei was lower than 1.0. The difference in the Th1-like response of the Ig subclasses may be part of the reason why vaccination with the C. burnetii can lead to a protective response, while vaccination with B. mallei does not.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Conference paper |
| Pages: |
8 |
| Report Date: |
01 JUL 2003 |
| Report Number: |
A840384 |
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