Rats were trained to press a lever under a multiple schedule of food or water reinforcement. Food-maintained response rates were reduced due to peripheral factors by atropine and methylatropine, while the selective central muscarinic antagonist N-(diethylamino-2-butynyl) succinimide (DKJ-21) had little effect. The AChE inhibitor physostigmine suppressed responding maintained under food reinforcement. DKJ-21, but atropine, was an effective antagonist of the rate-suppressing effect of physostigmine. Intraperitoneal (i.p.) administration of soman (5-40 ug/kg) reduced response rates in a dose-dependent manner. The suppression resulted from gastrointestinal spasm following inhibition of AChE in the gut. Thus, the i.p. route cannot be used for behavioral studies of soman. Subcutaneous (s.c.) injection of soman (70-90 micrograms/kg) suppressed food- and water-maintained response rates at doses only slightly below those that produced seizures and generalized toxicity. Behavior-disrupting doses of soman were administered to individual animals on 10-15 occasions without manifest chronic intoxication or permanent disruption of steady-state performance. (AW)
Final rept. 1 Jul 82-30 Jun 84
29 OCT 86
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