Abstract: The goal of this research is to use high spectral and spatial resolution (HiSS) MR imaging to improve images of human and murine prostate. Our work on the application of HiSS to improve anatomic and functional imaging was first described in a paper in Academic Radiology 1. Related work from this laboratory is presented in a number of other publications 2-9. Work from other laboratories shows that closely related methods also provide advantages for anatomic 10 and functional 11-14 MRI. This significant body of work provides support for the feasibility of ongoing experiments in this laboratory. Specifically, we expect to 1) improve separation of water and fat signals 2) increase image contrast 3) increase sensitivity to contrast agents and to local physiology - and as a result improve detection of suspicious lesions such as cancers and particularly delineation of tumor edges. We expect that this will increase the sensitivity and specificity of MR scans for prostate cancer. To achieve these goals our original statement of work' is summarized as follows:
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 24 Dec 2001-23 Dec 2002 |
| Pages: |
7 |
| Report Date: |
JAN 2003 |
| Contract Number: |
DAMD17-02-1-0033 |
| Report Number: |
A786614 |
|
|
|
|
Keywords relating to this report:
