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Abstract:
The subacute toxicity following intravenous administration of a proposed resuscitation fluid, hypertonic saline/Dextran 70 (HSD), was evaluated in male and female New Zealand White rabbits. Animals received intravenous doses of HSD, at levels of 8, 12, and 16 ml/kg/day over a 5-minute period, daily for 14 days. Equal volumes of each HSD component, 7.5% hypertonic saline (HS) and 6% Dextran 70 (D70) in normal saline, were also evaluated. Ringer's lactate (RL), dosed at 16 ml/kg/day, served as the control. Blood samples were collected for serum chemistry and hematologic analyses on Days -7 and 0 (baseline), Days 1, 2, 3, and 7 before daily administration of the dosing solutions, and Day 14 before necropsy. Observations were made daily before dosing, 1 hour after dosing, and in the afternoon. Water consumption was monitored over a 24-hour period weekly during quarantine, daily for the first week of the study, and on Day 14. The animals in each group were euthanized are submitted for necropsy on Day 14. The majority of clinical signs were observed with relatively equal incidence among the treatment and control groups. Clinical signs observed with increased frequency in the HSD-, HS-, and D70-treated groups included hyperactivity and apprehension. The incidence and severity of observed signs was greatest 1 hour after dosing, and declined over the following 24 hours until dosing was repeated the next day.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Rept. for 30 Mar-21 Jun 89 |
| Pages: |
935 |
| Report Date: |
NOV 89 |
| Report Number: |
A713612 |
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