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Abstract:
This work describes the development of a novel system for efficient and rapid introduction of genes into specific tissues or cells in mice. Detailed analysis of gene function often relies upon introduction of genes into an animal model system. We are developing a retroviral-based system in which controlled expression of the cellular receptor for the virus in a defined pattern determines the site(s) of infection. Using this retroviral gene delivery system, a gene can be introduced not only in a spatial-specific pattern but also in a temporally-controlled manner using a retroviral vector. For these studies we expressed the receptor for the avian virus Rous sarcoma virus in mammary cells in transgenic mice.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept 1 Sep 95-31 Aug 96 |
| Pages: |
16 |
| Report Date: |
SEP 96 |
| Contract Number: |
DAMD117-94-J-4183 |
| Report Number: |
A646233 |
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