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A Problem-Solving Environment for Biological Network Informatics: Bio-Spice

Authors: Patrick Lincoln; Charles J. Pedersen; SRI INTERNATIONAL MENLO PARK CA
Abstract:
The integration of multiple bioinformatics tools into an integrated suite poses many software engineering, social, and research challenges. We present our work on Bio-SPICE, an integrated open-source framework of tools for modern biology. SRI led the integration tasks, bringing together a community of researchers and practitioners to agree on a set of standards and practices that enabled multiple tools from multiple institutions to be brought to bear on problems of interest to biologists working on DoD-relevant problems. Working through communication and cultural barriers, the Bio-SPICE community developed good working relationships and built a series of impressive use cases, highlighting the effectiveness of combinations of computational tools from multiple sources working together on a common problem. This report documents the efforts at SRI International in leading the integration and combining research efforts across the Bio-SPICE program, including the development of the Bio-SPICE user interface, standards, and community working groups.

Limitations: APPROVED FOR PUBLIC RELEASE
Description: Final technical rept. Sep 2001-Oct 2006
Pages: 142
Report Date: JUN 2007
Contract Number: F3060201C0153, DARPAORDERM293
Report Number: A593174
Keywords relating to this report:
*INTEGRATION
*SOFTWARE ENGINEERING
BIOLOGISTS
MODELS
PROBLEM SOLVING
SIMULATION
SOFTWARE TOOLS
STANDARDS
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