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Abstract:
Studies have centered on exploring the oral transmission of filarial parasites to definitive hosts, and on the escape of third-stage (L-3) filarial parasites from infected mosquito intermediate hosts. The major findings include: Brugia pahangi L-3s were successfully recovered from jirds 10-11 days after oral exposure. Unaesthetized adult jirds proved less susceptible to oral infection with B. pahangi than did anesthetized controls, while unanesthetized neonatal jirds proved highly susceptible to oral infection; Dipetalonema viteae, however, matured only infrequently when given orally to adult or neonatal jirds. Experiments with L-3s of Brugia malayi in anesthetized adult jirds indicate that in most respects this parasite shares with B. pahangi similar capacities to infect jirds by mouth. When beagle puppies, anesthetized or not, were exposed orally to B. pahangi L-3s, infections matured in all the dogs; infections were heavier in dogs exposed with than without anesthetic. Previous work having shown that B. pahangi L-3s readily escape into water from dead or dying Aedes aegypti, the present studies disclosed the same escape phenomenon among B. pahangi-infected Armigeres subalbatus, Anopheles quadrimaculatus, and Aedes togoi, as well as among B. malayi-infected Ae. aegypti and Ae. togoi.
| Description: |
Final rept. 1 Oct 73-31 Dec 75 |
| Pages: |
48 |
| Report Date: |
26 JAN 1976 |
| Contract Number: |
DAMD1774C4038 |
| Report Number: |
A588320 |
Report Unavailable |
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