Multiplication and Virulence of Septicemic and Blood Pathogens in the Organism of Infected Animals and in Their Carcasses: Report 6. Study of a Model of Experimental Inoculations With Listeria Monocytogenes,

Authors: Al. Toshkov; D. Velyanov; Iv. Kaloyanov; ARMY BIOLOGICAL LABS FREDERICK MD

Abstract:

On the basis of these experiments it was established that simultaneously with a comparatively moderate postmortal multiplication of Listeria monocytogenes in the tissues there takes place as well an extraordinary intensification of its virulence. No multiplication is observed in the blood of experimental animals. It is noted that temperature changes affect the rate at which multiplication takes place and virulence increases after death. The increase of virulence in the carcass takes place in the following order: at 28C 10,000-fold by the 24th-36th hour; at 18C 3,000-fold by the 24th hour; and at 0- 4C 3,000-fold by the 36th hour. The slight increase in virulence during the disease (up to 60-fold in comparison with initial virulence) and the sharp rise after death (up to 10,000-fold) emphasize the important role of carcasses as a significantly more dangerous reservoir and source of infectious outbreak than the organism of animals suffering from listeriosis.

Limitations:

APPROVED FOR PUBLIC RELEASE