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Abstract:
The goal of this research is to develop stable radioimmunoconjugates (RICs) of an anti-HER 2/neu antibodies (MoAbs) for imaging and therapy in an animal model bearing human breast tumors. Pharmacy-grade Herceptin and an anti- HER2/neu antibody were conjugated with a DTPA linker. InCl(3)111 and YCl(3)90 were labeled to MoAb-CHX-A"-DTPA according to the procedure of Clarke et al. (Cancer Res 60: 4804, 2000). Binding capacity of RICs was tested with human cancer cell lines MCF-7, HCC-1954, BT-474 and SKBR-3.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Final rept. 1 May 2001-30 Apr 2003 |
| Pages: |
33 |
| Report Date: |
MAY 2003 |
| Contract Number: |
DAMD17-01-1-0271 |
| Report Number: |
A490814 |
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