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Abstract:
At least five distinct genetic subtypes(genotypes) of HIV 1 have been identified by DNA sequencing. Current vaccine candidates are based on virus strains from North America & Europe that represent only one subtype. The extent to which distinct genotypes of HIV-1 correspond to antigenically distinguishable serotypes is largely unknown and may be critically important to vaccine design. Cross-neutralization studies were done with viruses & plasma from 2 different genotypes. Based on neutralization susceptibility, 10 primary HIV-1 isolates from Thailand & the U.S. were classified into one of two antigenic subtypes that correlated with viral genotype. The existence of serotypes of HIV-1 suggests that a broadly effective vaccine may have to include strains from multiple subtypes. Neutralization of these primary HIV-1 isolates differed substantially from results with laboratory strains. Future neutralization studies using primary isolates and multiple genotypes may be important-for assessment of HIV-1 antigenic diversity. HIV-1(Human Immunodeficiency Virus Type 1), Neutralization studies, Antegenic subtype.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Pages: |
8 |
| Report Date: |
1994 |
| Report Number: |
A413572 |
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