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Abstract:
Work in our laboratory on breast development and tumorigenesis has focused on the Cripto gene, which encodes an extracellular protein that is a member of the EGF-CFC gene family. Several lines of evidence have indicated that Cripto to is involved in autocrine or paracrine signaling during human breast carcinogenesis (reviewed in (Salomon et al. 1999)). In particular, Cripto is overexpressed in a large percentage of human breast cancers, but not in normal breast tissue (Qi et al. 1994), and Cripto has transforming activity when overexpressed in NOG-8 mouse mammary epithelial cells (Ciardiello et al. 1991). To investigate the role of Cripto in breast development and tumorigenesis, I have been analyzing the molecular mechanisms of Cripto protein activity, with the objective of identifying a putative Cripto receptor(s).
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Final rept. 13 Apr 1998-12 Apr 2001 |
| Pages: |
17 |
| Report Date: |
MAY 2001 |
| Contract Number: |
DAMD179818149 |
| Report Number: |
B406472 |
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