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Abstract:
In order to evaluate the compatibility of structured nanoparticles produced by aqueous emulsion polymerization with the non-covalent imprinting procedure, a number of imprinted polymeric nanoparticles have been synthesized by seeded emulsion polymerization in the presence and absence of a porogenic solvent. Propranolol was chosen as the template molecule using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EDMA) as functional monomer and crosslinker respectively. The influence of the porogen and the amount of template added was studied by measuring the capacity of the polymeric particles to rebind template both in organic and aqueous buffers by radioligand binding assay. By increasing the amount of template from 0.5 to 6% (mol/mol with respect to monomers) the specific rebinding was increased from 2% to 24% in aqueous buffer and to 31% in a toluene based assay. The influence of the porosity was also established when the rebinding was performed in an organic solvent.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Conference paper |
| Pages: |
6 |
| Report Date: |
21 MAY 2003 |
| Report Number: |
P406310 |
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