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Abstract:
We are conducting a large case-control study, nested within a prospective cohort, to estimate relative risk of breast cancer in post- menopausal women by levels of urinary estrogens and estrogen metabolites, and to examine the association between the concentrations of these hormones and breast cancer risk with polymorphic variations of a series of candidate genes, known to be implicated in the regulation of estrogen metabolites synthesis. In this second year of the project, the personnel hired in Dr. Kurzer's laboratory (University of Minnesota) have been trained, and urinary analyses started. Unfortunately due to a lack of sensitivity of the method used, and to a partial degradation of the estrogen metabolites in the DOM samples, the measurements were stopped after the analyses of 30 urine samples, since for more than half of the samples, less than 50% of the analytes could be measured. Tests to implement the detection limit of the method re done, with limited success. Our study encountered some major problems in the analyses of the urinary estrogen metabolites in the DOM samples, and therefore it is substantially delayed. Alternatives to the current method used for these analyses are proposed.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 1 Sep 2003-31 Aug 2004 |
| Pages: |
7 |
| Report Date: |
SEP 2004 |
| Contract Number: |
DAMD17-02-1-0422 |
| Report Number: |
A389334 |
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