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MedicineAnatomy and Physiology

Genetic and Hormonal Risk Factors for Prostate Cancer in African American Men

Authors: Aruna V. Sarma; MICHIGAN UNIV ANN ARBOR
Abstract:
African American men are at greater risk for developing and dying from prostate cancer compared to white men. This disparity is likely due to a number of factors including environmental and genetic factors. The Flint Men's Health Study (FMHS) was established in 1995 as a population-based case-control study of African American men aged 4C-%9 residing in Genesee County, Michigan. The initial sample consisted of V3O men who completed an in-home interview consisting of potential risk factors for prostate cancer; medical history; and demographic data. 431 men provided a blood sample and 3%9 men who were determined to be free of cancer completed a comprehensive urologic exam. Additionally, 119 cases of prostate cancer have been identified from the same population. Studies have suggested a role for hormones and genetics in cancer incidence. However, studies have been completed in white populations and results have been conflicting. The objective of this study is to more clearly delineate the potential role(s) of selected hormones %nd growth factors in prostate cancer development.

Limitations: APPROVED FOR PUBLIC RELEASE
Description: Annual rept. 1 May 2004-30 Apr 2005
Pages: 68
Report Date: MAY 2005
Contract Number: DAMD170310270
Report Number: A386244
Keywords relating to this report:
AFRICAN AMERICANS
GENETICS
HORMONES
MALES
MEDICAL RESEARCH
POLYMORPHISM
POPULATION
PROSTATE CANCER
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