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Abstract:
This DOD grant aims to identify biomolecules that are crucial in the pathogenesis of prostate cancer. In the first year we found that miR-125b directly targets p53, Puma and Bak1. In the 2nd year, we focused on Aim 2 and have obtained exciting results: 1) miR-125b promotes prostatic tumor growth and also induces castrate-resistant growth in a mouse model; 2) miR-125-mediated suppression of apoptosis signaling contributes to the growth of CaP cells; and 3) our finding that miR-124 regulates the cellular levels of miR-125b in CaP cells provides a mechanistic explanation for up-regulation of AR/miR-125b signaling in CR CaP cells. Support from this DOD grant has lead to two published papers. One paper addresses the oncogenic activity of miR-125b in CaP cells and the other evaluates the effect of miR-106b on radiation resistance of CaP cells.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 15 Aug 2010-14 Aug 2011 |
| Pages: |
29 |
| Report Date: |
Sep 2011 |
| Contract Number: |
W81XWH-09-1-0583 |
| Report Number: |
A380455 |
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