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Abstract:
The study presented in this report is concerned with the preparation of analogs of (WR2721) with modifications in the terminal amine function as potentially new prophylactic radioprotective agents. We have developed general methods for the synthesis of WR2721 analogs that possess amide (-C(=0)NHR), thioamide (-C(=S)NHR) and amidine (-C(=NX)NH2) terminal residues. In addition, we have developed methods for the synthesis of 2-thioxo-3-thiazolidines and 5,6- dihydro-1,2,4,3(4H)-dithiazinethiones as new sulfur masked analogs of (WR1065). During the contract period, a total of twenty-eight (28) target compounds were prepared and submitted for radioprotector screening. No test data is available at this time. Keywords: Synthesis(Chemistry).
| Description: |
Final annual rept. 15 Jun 85-14 Aug 87 |
| Pages: |
81 |
| Report Date: |
AUG 87 |
| Contract Number: |
DAMD17-85-C-5156 |
| Report Number: |
A306781 |
Report Unavailable |
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