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Abstract:
During the previous year, we completed the animal studies (first phase) of the proposed research using contrast enhanced magnetic resonance imaging for detecting tumor bearing nodes. The R323OAC mammary carcinoma or Freund's adjuvant was injected into the superior aspect of the foot which resulted in metastatic tumor or inflammatory nodes in the politeal area. Studies were done when the nodes were small (4-6 mm) to accurately model the clinical diagnostic question of whether patients have metastatic disease in the axillary nodes. A total of 8 sequences were studied to determine if AMI- 227 could enhance discrimination between tumor and inflammatory nodes. The fast spin echo (FSE) sequence resulted in best discrimination between inflammatory and tumor bearing nodes. Statistically significant differences were noted between the two groups but there was significant overlap between the two populations, suggesting that, for small nodes (4-6 mm), the technique may not be diagnostic.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 16 Sep 95-15 Sep 96 |
| Pages: |
14 |
| Report Date: |
AUG 1996 |
| Contract Number: |
DAMD17-94-C-4064 |
| Report Number: |
A300643 |
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Keywords relating to this report:
