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Abstract:
This project aims to identify adult prostate stem cells using tissue recombination technology. To date we have successfully directed the differentiation of mouse and human embryonic stem (ES) cells as outlined in the original statement of work. We have shown pathologically and histologically that the resultant tissue recombinants are highly characteristic of mouse and human prostate. We have refined the technology so that we reliably get prostate like tissues 0 the absence of spontaneous dlfferentiation of ES cells into non-prostate like tissues. We are currently restrained by the technology associated with the transfection of human embryonic stem cells but hope to complete all the tasks of the project during 2005. This work has been present a total of 6 meetings including both national meetings within Australia internationally in the USA. We plan to publish the initial findings early in 2005. Work is ongoing to tag and solate epithelial cells from these tissues in order to identify the adult prostate stem cell.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Final rept. 1 Mar 2003-28 Feb 2006 |
| Pages: |
22 |
| Report Date: |
MAR 2006 |
| Contract Number: |
DAMD170310151 |
| Report Number: |
A262654 |
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