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Abstract:
Mammographic breast density is one of the strongest known risk factors for breast cancer, and a marker of cancer risk for both breasts. Information on the etiology of breast density is currently limited. To gain further insight into the role of inflammatory cytokines in the etiology of breast density, this study investigates associations between serum cytokine levels, genetic variation in cytokine genes, and breast density using data and samples from the Mammograms and Masses Study. This report provides information on the progress made during the third year of the grant. MAMS study participants were genotyped for common single nucleotide polymorphisms (SNPs) in or near IL6, IL6R, IL6ST, TNF-alpha, TNFRSF1A, and TNFRSF1B using MassARRAY iPLEX Gold (Sequenom). Analyses of the genotype data are ongoing. Preliminary results suggest that, in healthy postmenopausal women, common variation in IL6R and IL6ST is associated with percentage breast density. None of the evaluated SNPs in IL6 and TNF-alpha were significantly associated with percentage breast density in this study population.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Annual rept. 1 Jul 2008-30 Jun 2009 |
| Pages: |
10 |
| Report Date: |
Jul 2009 |
| Contract Number: |
W81XWH-06-1-0533 |
| Report Number: |
A252955 |
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