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Abstract:
The more significant research contributions of the project toward solution of canine ehrlichiosis or tropical canine pancytopenia (TCP) will be cited. The development of the monocyte culture technique for in vitro propagation of the causative agent, the rickettsial Erhlichia canis, constituted an essential step toward successful studies of the agent and the disease. This technique provided for the first time a means of growing the organism in a system other than the dog, the natural mammalian host. Growth of the organism in monocyte cultures led to the development of antigens for serologic and immunologic studies. An indirect fluorescent antibody (IFA) test was developed and extensively used to detect E. canis infections among military dogs in and outside the United States and to monitor preventive and therapeutic measures for control of the disease. The antigen generated by the cell cultures also proved to be effective for in vitro tests of cell-mediated immunity(CMI).
| Description: |
Final rept. 1 Oct 69-31 Dec 79 |
| Pages: |
15 |
| Report Date: |
31 DEC 1979 |
| Contract Number: |
DADA17-70-C-0044 |
| Report Number: |
A239621 |
Report Unavailable |
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