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Abstract:
The present study evaluated serum dextran concentration and its molecular size distribution following infusion of 7.5% NaC1/Dextran-70 (HSD) or Dextran-70 alone (D-70) at doses as high as the maximum tolerated dose (MTD). In the first set of experiments beagle dogs were infused i.v. with a single MTD of HSD or D-70 (20ml/kg). At 6h post-infusion, serum dextran concentrations were 15% higher in the D-70 group than the HSD group, but no significant differences were detected at the later times. In other studies, daily infusion of 2,3, or 4 times a 4 ml/kg dose of HSD or D-70 for 14 d in rabbits resulted in a dose- dependent, progressive rise in plasma dextran concentration. Molecular sizing of dextran in serum at 14 d revealed a shift from 70,000 to 90,000 M.W., reflecting the typical retention of the larger dextran fractions seen following a single bolus infusion. Despite the repeated infusions, molecular size distribution of dextran in serum indicated no impairment in excretion of lower molecular weight components. With repeated dosing no significant differences were observed between dextran concentrations following HSD or D-70 infusions.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Pages: |
27 |
| Report Date: |
OCT 90 |
| Report Number: |
A229532 |
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