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Abstract:
The aim of this project has been to develop a general method for constructing effective vaccines containing relevant peptides of pathogens linked to carrier molecules of optimized chemistry and geometry. We have synthesized, size-fractionated, characterized and studied the immune response to a series of model haptenated polymers. This has yielded information as to the best kind and size of carrier molecule as well as the optimal number and spacing of hapten peptides to yield an optimally immunogenic vaccine. Based on this data, a first- try vaccine was synthesized containing a synthetic P. falciparum CS peptide linked to carrier dextran. This multivalent peptide-dextran has proven to be immunogenic in mice after only one injection, in saline, without the use of adjuvants of any kind. Further studies are planned utilizing other relevant peptides as haptens and synthetically polymerized proteins as carriers.
| Description: |
Annual rept. 15 Oct 85-14 Oct 86 |
| Pages: |
17 |
| Report Date: |
23 DEC 86 |
| Contract Number: |
DAMD17-86-C-6038 |
| Report Number: |
B212011 |
Report Unavailable |
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