South Africa dismantled its nuclear weapons program in 1991, chemical and biological warfare program in 1993, and missile program in 1994 and became a disarmament trendsetter in bringing to signature an African Nuclear Weapons Free Zone in 1995 and compromise in Nuclear Non-Proliferation Treaty (NPT) review conferences in 1995, 2000, and 2005. Despite the South African government's continuing commitment to WMD nonproliferation and arms export controls, several issues related to WMD proliferation remain. This paper examines proliferation problems and transnational networks that are tied to South Africa's history as a developer of weapons of mass destruction and other weapons during the apartheid era (1948-1994). The problem of nuclear proliferation is examined through the lens of the recent A.Q. Khan case and involvement by a South African network. The problem of biological weapons proliferation is illustrated through the recent case of Dr. Daan Goosen--a key scientist in the 1980s biological warfare program (Project Coast) and the former director of the Roodepoort Research Laboratories. The problem of terrorism and transnational networks is examined using evidence of al-Qaeda activities and those of related groups in South Africa. Links are drawn between WMD proliferation supply and terrorist networks and indications and warning of WMD terrorism emanating from South Africa are examined.