Abstract: The antibody profile during and after the six-dose primary vaccination series with anthrax vaccine adsorbed (AVA, BiothraxTM)was characterized in 86 human volunteers. Ninety-three percent of recipients developed IgG antibodies to Bacillus anthracis protective antigen (PA) after two doses, and 100% were seropositive after dose #3. Geometric mean concentrations (GMC) of IgG to PA measured before and after each dose were significantly lower after injection #3 (peak GMC = 146.65 micrograms /mL, trough GMC = 15.16 micrograms/mL) than after injections #4 (peak GMC = 430.46micrograms/mL, trough GMC 96.19 micrograms/mL) (p < 0.0001 for each); but not between injections #4, #5 and #6, or #4 and #6 (p
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Pages: |
8 |
| Report Date: |
24 JAN 2006 |
| Report Number: |
A104944 |
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