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Abstract:
This study investigated the carcinogenic and immunotoxic potential of embedded fragments of depleted uranium (DU) and a heavy-metal tungsten alloy (WA) consisting of tungsten, nickel, and cobalt. Male Fisher 344 rats were surgically implanted with pellets of DU, WA, tantalum (inert metal, negative control), or nickel (known carcinogen, positive control). Implanted WA resulted in the rapid formation of tumors, identified as rhabdomyosarcomas, surrounding the pellets. These tumors had, within the same area, histopathological characteristics of both the pleomorphic and embryonal subtypes of rhabdomyosarcomas. Eventually these tumors metastasized to the lung. Rats implanted with tantalum or DU pellets did not develop tumors at the implantation site. In addition, WA-implanted rats (high-dose group) exhibited splenomegaly and hematological changes suggesting polycythemia as early as 1 month after pellet implantation.
| Limitations: |
 APPROVED FOR PUBLIC RELEASE |
| Description: |
Final rept. 17 Sep 2001-16 Sep 2006 |
| Pages: |
73 |
| Report Date: |
OCT 2006 |
| Contract Number: |
DAMD170110821 |
| Report Number: |
A104854 |
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