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Low Molecular Weight Leachables From Medical Grade Polymers

Authors: B. F. Howell; S. Chesler; L. Hilpert; D. J. Reeder; NATIONAL BUREAU OF STANDARDS GAITHERSBURG MD
 
Abstract: Four medically important polymeric materials (silicone polymer from mammary prostheses, polyurethane, polyethylene, and polycarbonate) were placed in contact with water for time periods ranging from four hours to seven days. Substances leaching into water were separated by extraction with methylene chloride, or by evaporation of water, and identification of species in the leachate was attempted by a number of analytical techniques, with extensive use of combined gas chromatography/mass spectrometry (GC/MS). Low molecular weight fragments of dimethylsiloxane were identified from mammary prosthesis gel. Spectra are also included for leachate from the other three polymers; identification of these compounds is still in process.

Limitations: APPROVED FOR PUBLIC RELEASE
Description: Final rept.
Pages: 35
Report Date: APR 82
Report Number: A100303
Keywords relating to this report:
CHLORIDES
EVAPORATION
EXTRACTION
FRAGMENTS
GAS CHROMATOGRAPHY
IDENTIFICATION
LEACHING
LIGHTWEIGHT
MASS SPECTROMETRY
MATERIALS
MEDICAL SUPPLIES
MEDICINE
METHYLENES
MOLECULAR WEIGHT
POLYCARBONATES
POLYETHYLENE
POLYMERS
POLYURETHANE RESINS
SEPARATION
SILICONES
WATER
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